There are several ways that CBD can affect the brain. These benefits are listed below: Increase cerebral blood flow, Lower inflammation, Promote neurogenesis, and Improve memory. Let’s look at each of them in more detail. This will give you a better understanding of how CBD can help your brain. If you’re looking for a natural alternative to treat anxiety, CBD is a great option. It can also be used to treat other medical conditions, such as epilepsy.
Increases cerebral blood flow
In order to understand how the brain regulates its cerebral blood flow, we must first know what causes it. The brain’s autoregulation of cerebral blood flow relies on both flow-mediated and conducted vasodilation. When CPP falls below autoregulation, cerebral ischemia may result. In the absence of such mechanisms, cerebral ischemia may result. The following are some of the factors that increase cerebral blood flow.
Healthy cerebral blood flow is critical for proper brain function. About 20% of the blood supply supplied by the heart is dedicated to the brain. The steady flow of blood transports oxygen, glucose, and nutrients to the brain while carrying metabolic waste products away. Impairments in the blood flow to the brain can lead to cognitive problems, including memory loss. Some common causes of poor brain blood flow include low thyroid, abnormal blood pressure, infections, stress, and other factors.
The brain’s high metabolic demand requires tight regulation of cerebral blood flow. Acute hypoxia induces marked increases in cerebral blood flow. Acute hypoxia increases cerebral blood flow by increasing adenosine production, which decreases vascular resistance. Hypoxia also increases nitric oxide production and capillary density. Despite the underlying mechanisms, the brain’s high metabolic demand requires that blood flow is coordinated.
The effects of carbon dioxide on cerebral blood flow are well documented. A concentration of 5% CO2 in the blood causes cerebral artery dilation, which increases cerebral blood flow by 50%. When a patient is exposed to 7% CO2, the cerebral artery diameter increases by 100%. The mechanism for this phenomenon is still not fully understood, but it is a clear indicator of the effects of carbon dioxide on cerebral blood flow. Consequently, this method should be investigated in patients with cerebral artery disease.
CBD inhibits tumor growth and oxidative stress by modifying the ecosystem that is responsible for the development of various cancers. It restores normal levels of inflammation in cancer cells and may become a novel adjunct therapy in the treatment of glioblastoma. In glioblastoma, for instance, tumors have a higher expression of apelin, which is a pervasive enzyme produced by many cell types in the brain. It supports critical blood vessel growth and promotes the survival of cancer stem cells. Thus, inhibiting this enzyme can reduce the growth rate of this lethal brain tumor.
CBD inhibits oxidative stress by modulating the expression of multiple proteins. The chemical can also inhibit cellular margination in experimental models of inflammation and tissue injury. CBD reduces inflammatory signals in neurons and enhances the ability of the brain to recover from injury. Further, it also prevents cellular margination by inhibiting the expression of adhesion molecules and chemotaxis. In addition, it increases neurogenesis in BCCAO animals and promotes dendritic restructuring in COVID-damaged lungs.
In mouse models, CBD decreased the level of oxidative stress, a precursor of inflammatory response. Inhibiting this oxidative stress also boosted basal uptake of PoPo3, and lowered intracellular calcium levels. Further, CBD reduced the number of TNF-stimulated lymphocytes, a marker of chronic inflammation in the brain. The effects of CBD on mitochondrial dysfunction may be beneficial for the treatment of early-onset autoimmune diseases.
Cannabinoids inhibit the production of pro-inflammatory cytokines in animal models and human cell cultures. In addition, they inhibit the migration of immune cells and suppress the production of cytokines by macrophages and microglia. Finally, cannabinoids inhibit the production of IL-12 p40 subunit. These effects could lead to the development of potential therapies for inflammatory diseases.
Cannabinoids have gained increasing attention in recent decades, with PubMed publications relating to these compounds increasing from 379 in 2000 to 2473 by 2020. In fact, one search for the term “cannabinoids and neurogenesis” produced 232 results. This slow increase in publications indicates that the scientific community is slowly turning its attention to cannabinoids and neurogenesis as a therapeutic strategy. However, the question remains: do cannabinoids promote neurogenesis and how does this happen?
In a previous article, we explored the evidence regarding how CBD promotes neurogenesis in adult brains. This was an interesting finding, since it suggests that CBD may help reduce cognitive decline in Alzheimer’s patients. Moreover, CBD is known to bolster memory and focus, two important cognitive functions. This is one of the reasons that CBD has been shown to reduce memory loss. It could therefore help people with impaired episodic or long-term memory. However, it is important to note that CBD has limited evidence to enhance memory in healthy brains.
Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are known to negatively impact neurons, including those that are related to memory. In contrast, CBD promotes neurogenesis in patients suffering from these degenerative diseases. This is especially important if patients are losing neurons at an alarming rate. In one study, CBD treatments reversed the memory loss and cognitive impairment of mice undergoing a dementia-inducing treatment.
Adult neurogenesis occurs in the brain thanks to a subpopulation of stem cells known as neural stem cells. Neural stem cells are capable of self-renewing, dividing into astrocytes, neurons, and oligodendrocytes. In the adult brain, there are two distinct niches for neurogenesis: the subventricular zone of the lateral ventricle and the subgranular zone of the hippocampus.
The CBD compounds found in marijuana are said to have neuroprotective and memory-enhancing effects. The chemical also has anxiolytic and antipsychotic properties. Although the neurobiological underpinnings of these effects are not fully understood, they may represent an important new agent in the treatment of psychotic disorders. The aim of this review is to provide an overview of recent neuroimaging studies that have examined CBD’s acute effects on brain function. The review included articles published from May 20, 2020, and met certain inclusion criteria.
In studies, researchers have found that CBD improved cognitive function and improved movement in Alzheimer’s disease mice. These mice had previously been found to wander in tight circles. After administration of CBD, the mice started walking again, and their memory and cognitive functioning improved. Researchers believe CBD may be an effective treatment for dementia. As a neuroprotectant, CBD acts as a neurostimulant, reducing inflammation and decreasing oxygen buildup in the brain. Further, CBD is thought to improve movement, memory, anxiety, and stress.
The CBD effects on the brain are not only beneficial to people who suffer from Alzheimer’s disease, but may be useful for other disorders as well. Those with other neurological diseases may benefit from the CBD, as the properties of the substance affect blood flow to the brain. These improvements could also help patients with traumatic experiences. CBD is safe and well-tolerated and may be an effective treatment for many cognitive disorders. But there is still much research to be done before this new compound can be approved for medical use.
CBD’s neuroprotective effects on the brain are a positive one for those suffering from Alzheimer’s disease, as the chemical can interfere with certain medications. The neuroprotective properties of CBD may support memory function by preventing the breakdown of neurotransmitters. This means that it may improve memory and focus. Further studies are needed to confirm these findings. CBD is a natural remedy for Alzheimer’s disease and can be a valuable addition to any treatment regimen.
Reduces oxidative damage to the brain
There is a growing body of evidence linking increased cerebral oxidative stress with certain central nervous system disorders, including amyotrophic lateral sclerosis (ALS), Parkinson disease, and cerebrovascular disorders. The brain is a particularly susceptible organ to oxidative damage, because it uses large amounts of oxygen to produce energy. Its low levels of antioxidants and large concentrations of unsaturated fatty acids make it particularly susceptible to oxidative damage.
After a traumatic brain injury, the brain becomes highly susceptible to secondary oxidation due to the dysfunction of the mitochondria. In addition, increased levels of malondialdehyde and free radicals are generated, exacerbated by the insufficient amount of local antioxidants. Furthermore, these oxidative stress products promote apoptosis, damage nerve cell membranes, and cause lipid peroxidation. The antioxidant flavonoid, wogonin, inhibits the oxidation of nerve cells.
ROS have a role in neuroinflammation and apoptosis, but their exact mechanism is still not fully understood. Recent studies have shown that chronic schizophrenic patients treated with antipsychotic drugs have increased plasma SOD activities, a factor that negatively correlates with positive symptoms in this population. Other research has implicated glutathione peroxidase in the development of schizophrenia and has been linked to structural brain abnormalities.
There is also evidence supporting the benefits of polyphenols, which are organic chemicals with many health-enhancing properties. These compounds are commonly found in a variety of plant-based foods and healthy fats. Cacao powder, saffron, and other spices are rich sources of polyphenols. They reduce oxidation, inhibit proinflammatory cytokines, and induce mitochondrial biogenesis. By increasing polyphenol levels, polyphenols may improve brain health and lifespan.