A new study from Colorado researchers has found that cannabidiol (CBD) helps relieve symptoms of rheumatoid arthritis. While more research is needed, this doesn’t necessarily mean that more studies are necessary. While cannabinoids are effective at decreasing inflammation and pain, they are also associated with harmful side effects, especially when they are smoked. People with RA are at a greater risk for developing heart and lung problems, and smoking marijuana may exacerbate those conditions. Therefore, the Centers for Disease Control and Prevention (CDC) have issued warnings against the use of marijuana to treat RA.


Although more studies are needed to determine whether CBD or cannabis oil can help people with RA, there are already over 85 registered trials in the field. While these studies are promising, Dr. Alexander is cautious, cautioning that more studies do not necessarily mean a cure. While there is still an inconclusive way to tell if cannabis oil will work in RA, the anti-inflammatory effects of cannabinoids may have positive effects.

The most common method for taking CBD is through sublingual application. This method bypasses the digestive tract, preventing it from being degraded by stomach acid and liver enzymes. Consequently, it enhances the blood level of CBD, producing systemic effects – important for inflammatory arthritis. In contrast, CBD capsules and edibles don’t have this same systemic effect, and they often have low oral bioavailability, meaning only a tiny percentage of the CBD reaches the blood.

As with any medicine, the best way to use CBD for rheumatoid arthritis is with a doctor’s advice. There is no proof that CBD cures rheumatoid arthritis, but it can help to reduce pain. And while there are no studies that prove that CBD can help with chronic pain, the benefits are still considerable.

CBD has anti-inflammatory effects on RA synovial fibroblasts. CBD decreases their number and viability, reduces the production of IL-6/IL-8/MMP-3, and enhances intracellular calcium levels. The effects were enhanced when CBD was co-incubated with TNF pre-stimulation. Further studies are required to determine whether CBD increases the number and quality of RASF.

In addition to helping patients with rheumatoid arthritis, CBD has been linked to other positive effects. It blocks the metabolizing process of other chemical compounds in the body. The benefits of CBD in rheumatoid arthritis are well-documented. However, some people may not find it helpful in reducing their symptoms. The Arthritis Society recommends that medical cannabis be obtained under the supervision of a health care professional.

While CBD has been associated with reducing chronic pain, researchers have begun to extend its application to similar conditions. Rheumatoid arthritis is a type of autoimmune disease that causes the immune system to attack healthy cells in the joints. CBD-based sprays, like Sativex, are being investigated as an effective treatment for rheumatoid arthritis. Sativex is a cannabis-based spray that reduces inflammation, pain, and contributes to better sleep. In a human clinical trial, the drug has shown minimal adverse effects.

Synergy with anti-rheumatic drugs

Plants have complex pharmacological mixtures, and many have unique properties that may be beneficial when combined in a formula. Botanical extracts contain a variety of inactive and active constituents, which create ample opportunities for synergy. The pharmacological properties of these botanicals are still largely unknown, though.

A 2020 study details the interactions of CBD with the human body. It showed that CBD reduced RASF and increased intracellular calcium levels. In addition, CBD decreased inflammatory markers and inhibited the production of RASF, which is a substance that causes inflammation in the joints. Synovial fluid from RA patients treated with CBD had a reduced inflammatory response.

In addition to its anti-inflammatory properties, CBD also inhibits the production of IL-6 and MMP-3 in the RASF. It reduces cell viability by increasing intracellular calcium levels. CBD may also be helpful for rheumatoid arthritis because it targets RASF and activates mitochondrial targets.

While anti-rheumatic drugs may be effective for rheumatoid arthritis, cannabinoids must be targeting the right receptors. A CB2 agonist can reduce cytokine production, while a peripheral CB1 antagonist can prevent detrimental CB1 signaling. In addition, CBD may induce cannabinoid receptor-independent anti-inflammatory effects.

Side effects

The potential benefits of CBD for rheumatoid arthritis are numerous. The compound is non-psychoactive, with no detectable levels of tetrahydrocannabinol, the psychoactive component of marijuana. However, it does have a drowsy effect, which shows promise for the treatment of anxiety and sleep disorders. While there are no known cures for this ailment, conventional prescription medications are usually recommended. CBD for rheumatoid arthritis may be a safe and non-habit-forming alternative to opioid medications, and its mechanism of action is not yet fully understood.

Animal studies suggest that CBD is effective in relieving pain associated with RA, although quality human trials have not yet been conducted. However, many people who have tried CBD for RA have reported a reduction in pain and improvement in sleep. In addition to reducing pain, CBD can also reduce anxiety. However, it is important to consult with your healthcare provider before using CBD for rheumatoid arthritis to determine whether it is safe and effective for your condition.

CBD may have a protective effect on synovial fibroblasts in RA. During pre-treatment with TNF, CBD reduces the production of IL-6/IL-8/MMP-3, which is thought to be the hallmark of RA. This may be mediated by organic cation transporters and the effect of CBD on RA is dependent on a number of factors.

CBD may interact with other medications. Approximately 60% of CBD users for arthritis use the drug orally. This means that they take it orally as needed, often several times per day. Additionally, 69% of users expressed interest in using CBD for rheumatoid arthritis through oral applications. However, there are some side effects associated with CBD, including increased blood levels and increased risk of toxicity.

The results of this study indicate that CBD reduces cell viability, proliferation, and cytokine production. CBD also increases intracellular calcium and RASF levels. The effects of CBD were enhanced by pre-stimulation with TNF. These effects were mediated by TRPA1 and mPTp assembly, which are essential for cell survival. CBD may also affect RASF.

Side effects of cbd rheumatoid arthritis products

The endocannabinoid system controls the body’s functions and cannabinoids, including CBD, affect inflammation in many ways. One of its important roles is to inhibit the production of cytokines, which play a role in the development of inflammatory diseases. Recent studies suggest that CBD inhibits the production of cytokines in various organs, including synovial tissue, which is one of the areas most affected by RA.

The FDA does not regulate CBD products, but it does recommend that you choose a reputable brand. Always check with your doctor before taking CBD products, and start small and monitor side effects. Initially, you may experience mild side effects, such as a sore throat or a headache. You may also experience a decreased appetite, fatigue, or insomnia, which is common among users of CBD.

Willow bark, an ancient remedy for rheumatic diseases, has anti-inflammatory properties. Willow bark extract may help reduce pain perception, which in turn improves exercise performance. Aspirin is derived from willow bark, so it is an excellent source of CBD. One product on the market contains ten milligrams of CBD per gram. The 1,000-mg and 3,000-mg formulations contain sixty milligrams of CBD per gram.

Despite these potential side effects, many consumers of CBD rheumatoid arthritis pain relief are unlikely to consult their rheumatologist. In fact, more than two-thirds of respondents have not discussed CBD with their rheumatologist. These patients may be afraid that their opinions won’t be taken seriously. The fact is, it is important to understand the possible risks before using CBD in any way.